Bifunctional transfer-messenger RNA
نویسندگان
چکیده
منابع مشابه
Transfer rna dynamics and transfer-messenger rna accommodation in bacterial ribosomes at the single-molecule level
TRANSFER RNA DYNAMICS AND TRANSFER-MESSENGER RNAACCOMMODATION IN BACTERIAL RIBOSOMES AT THE SINGLE-MOLECULELEVEL byMAY DAHERDecember 2012Advisor: Dr. David RuedaMajor: Chemistry (Biochemistry)Degree: Doctor of PhilosophySingle-molecule spectroscopy, protein-induced fluorescence enhancement(PIFE), fluorescence resonance energy transfer (FRET), and several ...
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In bacteria, translation of mRNAs lacking stop codons produces truncated polypeptides and traps ribosomes in unproductive complexes. Potentially harmful truncated proteins are tagged with short peptides encoded by the mRNA-like domain of tmRNA and targeted for digestion by housekeeping proteases. We show that altered Escherichia coli transfer-messenger RNAs (tmRNAs) produce in vivo fusion prote...
متن کاملLon protease degrades transfer-messenger RNA-tagged proteins.
Bacterial trans translation is activated when translating ribosomes are unable to elongate or terminate properly. Small protein B (SmpB) and transfer-messenger RNA (tmRNA) are the two known factors required for and dedicated to trans translation. tmRNA, encoded by the ssrA gene, is a bifunctional molecule that acts both as a tRNA and as an mRNA during trans translation. The functions of tmRNA e...
متن کاملBacterial Identification Using Ssra Encoding Transfer-messenger Rna.
Abstract. Ribosomal DNA (rDNA) sequences are widely used for phylogenetic and bacterial identification. However, rDNA of different species often reveals similar or identical same sequences. This study employed the bacterial stable small RNA (ssrA) gene encoding transfer-messenger RNA (tmRNA) as a tool for identification of Staphylococcus aureus, Enterococcus spp, Pseudomonas spp and Enterobacte...
متن کاملrole of the transfer-messenger rna pathway _ trans-translation _ in bacterial physiology
tmrna (also known as ssra or 10sa rna) is so-named for its dual nature so that can function like trna and mrna. tmrna involved in a trans-translation reaction that truly is a kind of translational quality control system. this process contributes to the recycling of stalled translation complexes at the end of an mrna lacking a stop codon or at an internal mrna cluster of rare codons in a process...
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ژورنال
عنوان ژورنال: Biochimie
سال: 2011
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2011.05.029